La citometria a flusso è un metodo ampiamente utilizzato per analizzare l'espressione di molecole intracellulari e di superficie cellulare, caratterizzare e definire diversi tipi di cellule in una popolazione cellulare eterogenea, valutare la purezza di sottopopolazioni isolate e analizzare le dimensioni e il volume delle cellule. Consente l'analisi multiparametrica simultanea di singole cellule. Viene utilizzata principalmente per valutare la quantità di fluorescenza prodotta da anticorpi marcati con fluorescenza che vengono utilizzati per rilevare proteine o ligandi che si legano a particolari composti presenti nelle cellule, come il DNA quando è presente ioduro di propidio. Il processo di colorazione consiste nel realizzare una sospensione di singole cellule da tessuti o materiali di coltura cellulare. Le cellule vengono quindi trattate con anticorpi non marcati o marcati con fluorescenza in provette o piastre per microtitolazione prima di essere valutate su un citofluorimetro.
| ATTRIBUTO | DETTAGLI |
| Periodo di studio | 2020-2029 |
| Anno base | 2022 |
| Anno stimato | 2022 |
| Anno previsto | 2022-2029 |
| Periodo storico | 2018-2020 |
| Unità | Valore (MILIARDI DI USD) |
| Segmentazione | Per componente, per tecnologia, per funzione, per utente finale, per regione |
| Per componente |
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| Per tecnologia |
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| Per applicazione |
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| Da parte dell'utente finale |
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| Per regione |
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L'elevata domanda di strumenti per citometria a flusso è anche il risultato delle crescenti spese di R&S in biotecnologia , scienze della vita e attività di ricerca biofarmaceutica. Lo sviluppo della citometria a flusso microfluidica per i test Point-of-Care (POC) è un esempio dei nuovi e migliorati strumenti analitici introdotti dai miglioramenti tecnologici nella tecnica.
Flow cytometry, an analytical tool used in the measurement and analysis of physical characteristics of cells or particles, has emerged as a key tool for safety and exploratory purposes during the drug discovery and development processes. Its emergence as a crucial tool is largely due to technology's capacity to quickly examine a huge number of particles and produce statistically reliable information on the cell population. The main drivers of the market expansion are the expanding use of flow cytometry in clinical research and the growing usage of the technique in stem cell research. Additionally, its multi-parametric methodology is aiding flow cytometry's adoption in the processes of drug discovery and development.
The expanding emphasis on immunology and immuno-oncology research, the rising acceptance of flow cytometry techniques in research activities and clinical trials, and the expanding technical advancements are propelling the expansion of the global flow cytometry market. As the HIV population increases globally, there is an increasing need for diagnostic tools like flow cytometry.
The bioengineering industry has experienced tremendous expansion thanks to its applications in a number of fields, including drug discovery, cell culture, and stem cell therapy which is creating more opportunities for the flow cytometry market. The market is also predicted to grow due to the increase in the prevalence of infectious diseases and the growing demand for quick and precise cancer prognostic tools. In general, it is projected that expanding applications in the life science sector will fuel greater demand. The rise in healthcare organizations that support the adoption of high-quality treatments and medical procedures is more likely to be the root of the market's expansion.
Additionally, changing the flow cytometry region to minimize conflicts with several different antibodies within a flow cytometry panel has been increasingly popular in recent years. Recombinant antibodies have reduced the cost of flow cytometry by lowering the high background that frequently occurs when antibodies attach to Fc receptors. As a result, the development of recombinant DNA technology for antibody manufacturing in flow cytometry has opened up a variety of new commercial potential.
La disponibilità di sostituti superiori e più accessibili rappresenta un ostacolo sostanziale per il mercato della citometria a flusso. Questi sostituti includono ELISA e radioimmunoanalisi. ELISA e radioimmunoanalisi sono meno costosi e più facili da usare della citometria a flusso, nonostante il fatto che tutti e tre i metodi (citometria a flusso, ELISA e radioimmunoanalisi) aiutino a diagnosticare l'HIV localizzando le "cellule problematiche" in una popolazione di cellule. Si prevede che ci sarà un aumento della prevalenza di malattie croniche come il cancro e l'HIV, che migliorerà l'uso della citometria a flusso nelle applicazioni diagnostiche. Lo sviluppo del mercato della citometria a flusso, d'altro canto, si prevede sarà ostacolato da problemi quali apparecchiature e reagenti costosi, una mancanza di consapevolezza tra i potenziali utenti finali e una mancanza di competenza tecnica.
La pandemia di COVID-19 ha avuto un effetto positivo sulle prospettive del business della citometria a flusso durante l'epidemia iniziale di COVID-19. La crescente applicazione di reagenti nella ricerca e negli studi clinici ha aumentato la quota di mercato dei reagenti per citometria a flusso e quindi l'uso della tecnologia della citometria a flusso. Ad esempio, a marzo 2020, Cytek Biosciences Inc. ha fornito supporto a medici e ricercatori in tutto il mondo che stavano esaminando gli effetti del virus COVID-19 sui sistemi immunitari umani. L'uso di tecniche basate sulla citometria a flusso per la diagnosi del COVID-19 e la sorveglianza delle malattie ha favorito l'espansione del settore. Inoltre, la pandemia ha alimentato l'innovazione nello spazio della citometria a flusso, come dimostrato dall'introduzione di nuovi prodotti in questo campo.
The global Flow cytometry market revenue is projected to expand at a CAGR of 7.6% during the forecast period.
The global Flow cytometry market was valued at USD 4.28 Billion in 2020.
Some key players operating in the flow cytometry market include Agilent Technologies Inc., Becton Dickinson and Company, bioMérieux SA, Bio-Rad Laboratories Inc., Danaher Corporation, DiaSorin S.p.A., Miltenyi Biotec Inc., Sartorius AG, Sysmex Corporation, Thermo Fisher Scientific Inc.
Key factors driving the flow cytometry market growth include the rising R&D investments in the biotechnology sector and technological advancements in the field of flow cytometry for introducing new and improved analytical tools, such as microfluidic flow cytometry, for point-of-care testing.
North America region will lead the global flow cytometry market during the forecast period 2022 to 2029.
The flow cytometry market is segmented based on component, technology, application, end-user and region, global trends and forecast.
By component the market is bifurcated into instruments, Reagents and Consumables, Software, and Service; by Technology the market is bifurcated into Cell based and Bead based; by Application the market is bifurcated into Academic & Clinical applications and Diagnostic application; by End-user the market is bifurcated into Hospitals, Medical schools and clinical testing labs, Commercial organizations, Academic institutions, Others and Region.
Due to the development of novel instrument designs, the necessity for highly effective replacement components, applications in the treatment of emerging diseases, and an increase in research and advancements in flow cytometry techniques, the instruments segment held the largest market share in 2021. Reagents and consumables are crucial for flow cytometry analysis; hence they are predicted to overtake all other segments. Due to the combination of imaging capabilities and reagent consumption for enhancing the instrument performance and making it more affordable for emerging economies, the market share for flow cytometry reagents is anticipated to increase.
In 2021, the technology segment was led by the cell-based flow cytometry, which brought in more than 77.25% of the total revenue. Its dominance is influenced by rising demand for early diagnosis and growing understanding of the advantages of cell-based assays. The adoption is also anticipated to be fueled in the future by technological developments in cell-based assays, such as innovation in software, instruments, algorithms, affinity reagents, and labels. Bead-based flow cytometry is used to measure intracellular soluble proteins such as growth factors, cytokines, chemokines, and phosphorylated cell signaling proteins. The high-throughput flow cytometry technique is thought to be the best tool for performing multiplex bead-based assays. During the forecast period, the bead-based assay segment is expected to grow at a significant CAGR of more than.
Academic & clinical applications segment accounted for a significant share of the market share in the flow cytometry market in 2021, owing to an increase in research of academic & clinical applications of flow cytometry. However, due to the increased use of technology in diagnostic applications, the diagnostic applications segment is expected to grow at a rapid pace. In 2021, the academic institutes segment had a higher revenue share than other segments in terms of end-users. In cell biology and molecular diagnostic studies, the technique is used to measure cell parameters such as physical properties of cells, recognition of biomarkers via specific antibodies, cell type, cell lineage, and maturation stage. This technology can be used in a variety of educational settings, including molecular biology, immunology, pathology, plant biology, and marine biology. With increased R&D activities, the segment is expected to grow significantly during the forecast period. [caption id="attachment_14454" align="aligncenter" width="1920"]
The flow cytometry market key players include Agilent Technologies Inc., Becton Dickinson and Company, bioMérieux SA, Bio-Rad Laboratories Inc., Danaher Corporation, DiaSorin S.p.A., Miltenyi Biotec Inc., Sartorius AG, Sysmex Corporation, Thermo Fisher Scientific Inc., and others. 11 January 2023: BD (Becton, Dickinson and Company), a leading global medical technology company, introduced a new, robotic track system for the BD Kiestra microbiology laboratory solution that automates lab specimen processing, which may help to reduce manual labor and wait time for results.
24 January 2023: As part of a global, multiyear agreement, Thermo Fisher Scientific today announced it is working with AstraZeneca to develop a solid tissue and blood-based companion diagnostic (CDx) test for Tagrisso (osimertinib).The flow cytometry market by region includes North America, Asia-Pacific (APAC), Europe, South America, and Middle East & Africa (MEA).
The flow cytometry market is dominated by North America, which also generates the highest revenue. Throughout the length of the forecast, this region is expected to dominate this market. This result is attributable to the U.S.'s substantial investment in healthcare, highly developed healthcare infrastructure, and widespread usage of flow cytometry technology. Additionally, there is a considerable need for flow cytometry equipment for research needs due to the highly expected research activities by pharmaceutical corporations and research colleges.
The second-largest flow cytometry market is anticipated to be in Europe. Government funding and support for R&D initiatives, increased public knowledge of healthcare diagnostics, and an increase in the number of cancer patients in the area are all factors contributing to the market growth in this region. Additionally, the pharmaceutical business is expanding its research and development efforts, which is boosting the market in this area.
Due to the rising prevalence of autoimmune diseases, rising healthcare awareness, rising investments and collaborative activities in the healthcare sector, as well as expansions by market players in the region, Asia-Pacific is anticipated to experience the fastest growth in the flow cytometry market during the forecast period.
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