The naturally occurring building blocks, which serve as a primary information carrying molecules within a cell are nucleic acids. The storage and expression of genetic information is done by two primary type of nucleic acid, DNA and RNA.
The procedure by which DNA or RNA are separated from proteins, membranes, and other biological components is known as nucleic acid isolation. The quality of the isolation phase in the process is crucial because nucleic acids are essential to many of the molecular testing techniques used today. It is essential to ensure that the yield and purity of the nucleic acid isolation, which is the initial stage in the entire molecular process, fulfil the expectations. The downstream applications and the research domains can have different expectations. Lyse, bind, wash, and elute are the four fundamental processes of a nucleic acid isolation procedure. The cellular structure is first disrupted to produce a lysate. To liberate the nucleic acid, the cell and nucleus are split open. The nucleic acids are attached to a carrier. Because the nucleic acid has been released from the nucleus after the first lysate phase but is still mixed with cell debris and other insoluble material, it is possible to separate the nucleic acid after the binding step. Third, the target nucleic acid is purified to get rid of any remaining impurities by washing the mixture with certain buffers. In order to use the pure nucleic acid, it is often redissolved at this step in an elution buffer.
| ATTRIBUTE | DETAILS |
| Study period | 2020-2029 |
| Base year | 2021 |
| Estimated year | 2022 |
| Forecasted year | 2022-2029 |
| Historical period | 2018-2020 |
| Unit | Value (USD Billion) |
| Segmentation | By Product, by method, by type, by application, by end user |
| By Product |
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| By Method |
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| By Type |
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| By Application |
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| By end user |
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| By Region |
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The rising research and development activities in the genomic field is driving the growth of the Nucleic Acid Isolation and purification market. The growing needs of the healthcare sector are fulfilled by the pharmaceutical and biotechnology companies which heavily invest in such activities. One of the factors influencing the market is the increase in company partnerships in the biotech sector.
Another significant driver of revenue generation in the market for nucleic acid isolation and purification is the advancement of personalized medicine. Cancer tumor biopsies are increasingly using Next Generation Sequencing (NGS). Because the procedure uses a straightforward and common test that can identify cancer at an early stage, liquid biopsies are a desirable choice for cancer diagnostics. The biggest challenge in treating cancer is its early diagnosis, and NGS can successfully address this issue, driving up demand for NGS technology. Therefore, it is projected that increased NGS technology use will have a direct impact on the uptake of nucleic acid isolation and purification methods.
The high cost of analytical instruments hinders the growth of nucleic acid isolation and purification market. The cost of nucleic acid isolation and purification using kits and automated instruments is higher than conventional methods. Though these techniques offer significant benefits like simplifications in isolation processes, reductions in working times, increased safety and higher output, the cost limits their adoption. Along with the cost of instruments additional expenses for reagents, disposables and maintenance and training are added. Thus, institutes or companies with smaller budgets cannot afford these techniques.
The markets in the developing countries such as India, China, Mexico, Africa and Brazil are expected to offer growth opportunities for the nucleic acid isolation and purification market. The patient population rising in these countries is majorly attributing to the growth of the market. The healthcare industry is growing in these countries which is resulting in introduction of sophisticated analysis equipment. The adoption of genomic analysis is expected to increase as a result of these factors.
The covid-19 pandemic was a positive catalyst in the growth of the nucleic acid isolation and purification market. Specific assays and kits were being developed for rapid detection of SARS-CoV-2. Viral RNA Xpress Kit was launched for efficient and rapid viral RNA isolation.
The Nucleic Acid Isolation and Purification market size was 4.45 billion in the year 2021 and is expected to grow at a CAGR of 36.7 %.
North America held more than 36.7 % of the Nucleic Acid Isolation and Purification market revenue share in 2021 and will witness expansion in the forecast period.
The rising research and development activities in the genomic field is driving the growth of the Nucleic Acid Isolation and purification market
The Nucleic Acid Isolation and Purification market key players include Agilent Technologies, Bio-Rad Laboratories Inc., Danaher Corporation, F. Hoffmann-La Roche Ltd, GE Healthcare, Promega Corporation, Qiagen NV, and Thermo Fisher Scientific Inc, Takara Bio, Inc., Biogenuix.
The kits and reagents segment dominated the market for nucleic acid isolation and purification. The expansion of the market is primarily responsible for the widespread use of kits and reagents for DNA and RNA isolation in the preparation of samples and libraries. The segment is also being driven by the increasing use of kits and reagents in research investigations aimed at understanding both common and uncommon genome-based disorders. The instrument segment is expected to witness fastest growth in the forecast period.
The nucleic acid isolation and purification market was dominated by the North American region. The region held the largest revenue share of 36.7 % in the year 2021. The main factor driving market expansion in the area is the presence of established companies and their work on creating technologically advanced rapid purification and isolation systems. Additionally, the increasing financing initiatives for biotechnology research are accelerating the market's growth in the area.
The Nucleic Acid Isolation and Purification market is segmented based on Product, method, type, application, end user and region.
Based on the product, market is segmented into Kit, Reagent and Instrument. The kits and reagents segment dominated the market for nucleic acid isolation and purification. The expansion of the market is primarily responsible for the widespread use of kits and reagents for DNA and RNA isolation in the preparation of samples and libraries. The segment is also being driven by the increasing use of kits and reagents in research investigations aimed at understanding both common and uncommon genome-based disorders. The instrument segment is expected to witness fastest growth in the forecast period.
Between methods used for nucleic acid isolation and purification such as column-based, magnetic beads, reagent-based, magnetic beads segment dominated the market. It accounted for a share of 37.9 %. This method provides researchers and scientists with improves assay performance. This technique reduces the need for centrifugation, which typically causes nucleic acids to break.
Based on type market is sub segmented into genomic DNA, plasmid DNA, miRNA. Due to its expanding use in COVID-19 diagnostics and rising use of purified miRNA for the creation of the cDNA library, the RNA isolation and purification segment dominated the market for nucleic acid isolation and purification in 2020, accounting for the biggest revenue share of 53.6%. Several uses for these libraries exist, including clinical diagnostics, sequencing, and gene expression monitoring.
The applications of the nucleic acid isolation and purification market include precision medicine, diagnostics, drug discovery & development, agriculture and animal research. Among these, the diagnostics segment accounted for the largest revenue share in the year 2020. The significant market share can be attributed to the growing use of DNA and RNA isolation for disease detection in regular sample processing.
Among the end users of the market, hospitals and diagnostic centers accounted for the highest share of the market. The growth of the segment was due to the increasing demand for early and accurate diagnosis of diseases. Techniques for isolating and purifying DNA/RNA are proved to be effective diagnostic tools for even hereditary illnesses such sickle cell anemia, hemophilia A, and Tay-Sachs disease.
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The Nucleic Acid Isolation and Purification market key players include Agilent Technologies, Bio-Rad Laboratories Inc., Danaher Corporation, F. Hoffmann-La Roche Ltd, GE Healthcare, Promega Corporation, Qiagen NV, Thermo Fisher Scientific Inc, Takara Bio, Inc., Biogenuix.
Recent News May 12, 2022: Danaher joined bespoke gene therapy consortium (BGTC) for rare diseases. The BGTC will generate gene therapy resources that the research community can use to streamline gene therapy development for rare disorders, making the process more efficient and less costly. April 6, 2021: Promega Opened new Research & Development Facility Supporting Science at the Edge of Innovation. Kornberg Center incorporated energizing architectural design that bridges office and meeting spaces with advanced laboratories to foster flexibility in exploration and collaboration.The Nucleic Acid Isolation and Purification market by region includes North America, Asia-Pacific (APAC), Europe, South America, and Middle East & Africa (MEA).
The nucleic acid isolation and purification market was dominated by the North American region. The region held the largest revenue share of 36.7 % in the year 2021. The main factor driving market expansion in the area is the presence of established companies and their work on creating technologically advanced rapid purification and isolation systems. Additionally, the increasing financing initiatives for biotechnology research are accelerating the market's growth in the area. US is projected to lead the nucleic acid isolation and purification market. The novel detection techniques and molecular diagnostic represented by nucleic acid hybridization and nucleic acid sequence analysis are becoming significant in the medical industry.
Asia Pacific is the region with the greatest rate of growth. Rising economic growth, substantial life sciences research, an increasing patient population, government measures that are supportive, and the existence of numerous creative biotech companies in the area are all factors that are causing the market in the region to flourish. The rise in prevalence of chronic diseases such as cancer is propelling the demand for associated diagnostics and treatments. Hence, China is expected to emerge as highly remunerative nucleic acid isolation and purification market in the forecast period.In the European region, the increased usage in covid-19 detection encouraged the growth of the market. The European Medicine Agency in the U.K. is using nucleic acid tests for emergency use for detection of virus in patients. The increased investments by governments and private agencies are fueling the market growth in the region.
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